Page 7 - CUA 2020_Pediatric

Unmoderated Posters 2: Uro-Oncology, Pediatrics, Sexual Dysfunction, Transplant

UP-2.12 had a prostate cancer diagnosis, even when demographics, multimor-
Patient-reported quality of life measures 15 years post-radical bidity, and substance use were statistically controlled. Self-rated mental
prostatectomy: A matched comparison of open retropubic and health showed no differences between the two groups.
robot-assisted techniques Conclusions: While treatments make it possible for survivors of prostate
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1
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Tristan Juvet , Malek Meskawi , Laureano J Rangel , Paige Nichols , cancer to live long lives, it does not preclude the associative increase of
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Matthew T. Gettman 1 mental health issues in this population compared to men who did not
1 Urology, Mayo Clinic Rochester, Rochester, MN, United States; Urology, have a prostate cancer diagnosis. Results here suggest that preventative
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Université de Montréal, Montreal, QC, Canada efforts to reduce mental health burden among prostate cancer survivors
Introduction: Robot-assisted radical prostatectomy (RARP) has become is a health priority.
the most common surgical treatment option for clinically localized pros- References
tate cancer in the United States. Controversy continues to exist over the 1. Fervaha G, Izard JP, Tripp DA, et al. Depression and prostate cancer:
benefits of a robotic approach vs. open radical retropubic prostatectomy A focused review for the clinician. Urol Oncol 2019;37:282. https://
(RRP). Previous studies have failed to show a difference in oncological doi.org/10.1016/j.urolonc.2018.12.020
or functional outcomes. Short-term quality-of-life studies have also failed 2. Zenger M, Lehmann-Laue A, Stolzenburg JU, et al. The relationship
to show a significant difference between the two options. We report data of quality of life and distress in prostate cancer patients compared
on 15 years of followup using standardized quality-of-life questionnaires. to the general population. Psychosoc Med 2010;7:Doc02.
Methods: Survey data was obtained from patients who underwent 3. Courneya KS, Katzmarzyk PT, Bacon E. Physical activity and obesity
treatment for clinically localized prostate cancer from August 2002 in Canadian cancer survivors. Cancer 2008;112:2475-82. https://
to December 2005. Patients were matched 2:1 for surgical year, age, doi.org/10.1002/cncr.23455
preoperative prostate-specific antigen (PSA), clinical stage, and biopsy
Gleason grade. Patients were asked to fill out and return three standard- UP-2.14
ized questionnaires. Anxiety and depression symptoms in prostate cancer survivors
Results: A total of 452 patients completed and returned the survey. This from Atlantic Canada
included 156 patients treated with RARP, matched to 296 patients treated Gabriela Ilie , Rob Rutledge , Ellen Sweeney 3
1,2
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by RRP. Response rate was 70%. There were no significant differences 1 Community Health and Epidemiology, Dalhousie University, Halifax,
in clinicopathologic characteristics between both groups. In review of NS, Canada; Radiation Oncology, Dalhousie University, Halifax, NS,
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all questionnaires, a significant difference was only noted in the number Canada; Atlantic Path, Dalhousie University, Halifax, NS, Canada
3
of pads/diapers required in the past four weeks (p=0.04). The overall Introduction: Side effects associated with current forms of prostate cancer
rate of patients reporting surgical treatments for incontinence (2.1%) and treatment, particularly when combined forms of treatment are adminis-
erectile dysfunction (0.7%) were very low, with no significant difference tered, are extensive. Among them, mental health outcomes during survi-
1
between RARP and RRP. vorship appear to be quite prevalent. Here, we examine the association
2,3
Conclusions: There continues to exist few differences in quality-of-life between depression and anxiety symptoms in a population-based sample
measures between RARP and RRP at long-term followup. Key compo- of men living in Atlantic Canada and we compare current mental health
nents of the survey involving sexual function and continence showed no outcomes among prostate cancer survivors, survivors of any other form of
significant difference at 15 years’ followup. This represents one of the cancer except prostate, and men who never had a prostate cancer diagnosis.
longest followup periods to date comparing these treatment modalities. All Methods: The analytical sample consisted of 6585 male participants aged
additional variables regarding multiple facets of quality-of-life measures 49–69 years from the 2009–2015 survey cycle of the Atlantic PATH.
showed no long-term differences between both subgroups. Mild, moderate, or severe depression or anxiety indicators were primary
outcomes and were assessed using the Generalized Anxiety Disorder
UP-2.13 (GAD-7) scale and the Patient Health Questionnaire (PHQ-9). The pres-
Depression, psychological distress, self-rated mental health and ence of a lifetime history of prostate cancer, any other form of cancer
prostate cancer: An examination of a population-based sample except prostate, or absence any diagnosed form of cancer was main
of Canadian men predictor variable. Analyses were controlled for demographic factors and
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Louise Moodie , Gabriela Ilie 1,2,3 , Susan Kirkland , Rob Rutledge 3 survivorship time since diagnosis.
1 Community Health and Epidemiology, Dalhousie University, Halifax, NS, Results: An estimated 3.9% of men reported having had a history of prostate
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Canada; Urology, Dalhousie University, Halifax, NS, Canada; Radiation cancer diagnosis, 11.3% of men reported having had a history of any other
Oncology, Dalhousie University, Halifax, NS, Canada form of cancer except prostate, and 84.9% reported never having had a
Introduction: Having a prostate cancer diagnosis is often only the begin- history of a diagnosed form of cancer in their lifetime. Prostate cancer sur-
ning of a multitude of inter-related health issues that challenge the quality vivors had 2.45 and 2.05 statistically significantly higher odds of screening
1-3
of life of survivors and affect oncological outcomes. Here, we examine positive for current anxiety or depressive symptoms, respectively, compared
the association between prostate cancer and depression, self-rated mental to controls. Cancer survivors (not including prostate), however, had similar
health, and psychological distress in a national sample of Canadian men. current mental health outcomes compared to controls.
Methods: The analytical sample was based on cross-sectional data from Conclusions: Results may point to a silent epidemic of mental health
25 183 men (ages 47–65) who participated in either the tracking or issues among survivors of prostate cancer compared to other cancer
comprehensive cohorts of the Canadian Longitudinal Study of Aging survivors, and highlight the importance of a multidisciplinary effort to
(CLSA) survey. The CLSA is a national cohort study of adults from 10 prioritize and deliver comprehensive mental health support to prostate
provinces across Canada, who were surveyed (baseline) between 2010 cancer survivors in Canada.
and 2015. Logistic regression analyses, controlled for the complexity References
of the design, demographics, and lifestyle factors (multimorbidity and 1. Canadian Cancer Society’s Advisory Committee on Cancer Statistics.
substance use), evaluated the association between history of a lifetime Canadian Cancer Statistics 2015. 2015.
prostate cancer diagnosis, depression (CES-D10), psychological distress 2. Fervaha G, Izard JP, Tripp DA, et al. Depression and prostate cancer:
(K10), and self-rated mental health. A focused review for the clinician. Urol Oncol 2019;37:282. https://
Results: The prevalence of lifetime history of prostate cancer diagnosis in doi.org/10.1016/j.urolonc.2018.12.020
this national sample of Canadian men was 4% (95% confidence interval 3. Zenger M, Lehmann-Laue A, Stolzenburg JU, et al. The relationship
[CI] 3.7,4.4). Among survivors of prostate cancer, odds of presenting of quality of life and distress in prostate cancer patients compared
with clinical psychological distress (adjusted odds ratio [aOR] 1.52; 95% to the general population. Psychosoc Med 2010;7:Doc02.
CI 1.09, 2.11) and/or depressive symptoms (aOR 1.24; 95% CI 1.02,
1.51) was statistically significantly higher compared with men who never
CUAJ • June 2020 • Volume 14, Issue 6(Suppl2) S63