Page 8 - CUA 2020_Pediatric

2020 CUA Abstracts

UP-2.15 ingly important. Prostate cancer treatment, albeit effective, is plagued
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Mental health outcomes in men with a history of radical by a host of life-altering side effects, such as bladder, bowel, and sexual
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prostatectomy dysfunction, as well as significant mental health issues. Approximately
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Joshua White , Gabriela Ilie , David G. Bell , Gregory G. Bailly , Ricardo 60% of men with prostate cancer experience mental health distress, with
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A. Rendon , Ross Mason , Joseph Lawen , Rob Rutledge 2 10–40% having clinically significant depression. The goal of our study
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1 Department of Urology, Dalhousie University, Halifax, NS, was to evaluate the associative role of age at diagnosis, urinary function,
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Canada; Department of Radiation Oncology, Dalhousie University, multimorbidity, number of active forms of treatment, survivorship time,
Halifax, NS, Canada and social well-being on current mental health outcomes.
Support: Soillse Prostate Cancer Quality of Life Research Lab. Dalhousie Methods: A total of 129 men (mean age 62 years) with a history of prostate
Research Medical Foundation cancer who received active treatment for their diagnosis completed an
Introduction: Survivors of radical prostatectomy (RP) report poor quality- online survey between May 2017 and December 2018, assessing patient-
of-life outcomes. We report the burden of mental health issues in a reported quality-of-life outcomes. The primary outcome was a validated
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population-based cohort of men with a history of prostate cancer (PCa) assessment of mental health disorder: the Kessler Psychological Distress
who underwent RP to determine risk factors associated with poor mental Scale (K10). Urinary problems and social well-being were assessed using
health outcomes. the UCLA Prostate Cancer Index and the Functional Assessment of Cancer
Methods: A total of 144 men (aged 48–86 years, median 68) with a history Therapy-Prostate (FACT-P), respectively. Analyses were controlled for age
of PCa and RP completed an online survey from 2017–2018 assessing at diagnosis, multimorbidity, number of received treatments to date, and
patient-reported quality-of-life outcomes. The primary outcome was a survivorship time.
validated assessment of mental health disorder: the Kessler Psychological Results: A total of 14.7% men scored positive for current mental health
Distress Scale (0–50, with >20 being likely to have a mental health issues. The fitted logistic model was statistically significant X2(8)=28.67;
issue). Urinary problems were assessed using the International Prostate p<0.001. A logistic model to help predict who is more likely to screen
Symptom Score (0–35, with >7 indicating moderate/severe urinary symp- positive for mental health issues revealed that better urinary function,
toms). Relationship satisfaction was assessed using the validated Dyadic increased social well-being, higher age at diagnosis, and longer survivor-
Adjustment Scale (0–151, with >97 indicating relationship satisfaction). ship time were associated with a decreased probability of having mental
Analyses were controlled for age, comorbidities, and survivorship time. health issues at 0.97 (95% confidence interval [CI] 0.95, 0.99), 0.15
The analytical sample was 126. A multiple logistic analysis assessed the (95% CI 0.03, 0.73), 0.91 (95% CI 0.83, 0.99), 0.98 (95% CI 0.97, 0.99),
association between the stated predictors and current mental health status. respectively. Multimorbidity, bowel, and sexual function did not contrib-
Results: A total of 16.4% men scored positive for current mental health ute statistically significantly to the model.
issues; 60.3% of respondents reported mild urinary problems, while Conclusions: Here, we show an association between a prostate can-
39.7% reported moderate/severe urinary problems. The odds ratio (OR) cer diagnosis and increased rates screening positive for mental distress
was 4.49 (95% confidence interval [CI] 1.41,14.28) for presenting with among men in the Maritime provinces. These findings highlight the
mental health issues among men with moderate/severe urinary problems. importance of a multidisciplinary approach to the prostate cancer care
Being satisfied in a relationship was a protective factor for mental health and survivorship, using the skillset of physicians, nurses, mental health
issues (OR 0.2; 95% CI 0.05, 0.86), as was being older (OR 0.87; 95% CI experts, and physiotherapists.
0.79, 0.96). Survivorship time did not contribute statistically significantly References
to the model. 1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA
Conclusions: Men with prostate cancer undergoing RP are at increased Cancer J Clin 2015;65:87-108. https://doi.org/10.3322/caac.21262
risk of mental health illness. In this study, we showed that younger men, 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J
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men with moderate/severe urinary symptoms, and men reporting relation- Clin 2018;68:7-30. https://doi.org/10.3322/caac.21442
ship dissatisfaction were found to be at higher risk for mental health issues. 3. Donovan JL, Hamdy FC, Lane JA, et al. Patient-reported outcomes
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https://doi.org/10.1016/j.urolonc.2018.12.020 men’s psychological and decision-related adjustment after treatment
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UP-2.16 urolonc.2011.02.002
An examination of the relationship between oncological
treatment and biopsychosocial quality-of-life outcomes in
Maritime prostate cancer survivors actively treated for their UP-2.17
malignancy The androgen deprivation therapy educational program: A
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Tarek Lawen , Gabriela Ilie 1,2,3 , David Bell , Ross Mason , Gregory G. Canadian resource that supports prostate cancer patients in
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Bailly , Ricardo A. Rendon , Joseph Lawen , Rob Rutledge 2 managing hormone therapy side effects
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1 Department of Urology, Dalhousie University, Halifax, NS, Lauren M. Walker , Erik Wibowo , Carly S. Sears , John W. Robinson ,
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Canada; Department of Radiation Oncology, Dalhousie University, Andrew G. Matthew , Deborah McLeod , Richard J. Wassersug 6
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Halifax, NS, Canada; Department of Community Health and 1 Oncology, University of Calgary, Calgary, AB, Canada; Oncology,
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Epidemiology, Dalhousie University, Halifax, NS, Canada Division of Psychosocial Oncology, Tom Baker Cancer Centre,
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Introduction: Prostate cancer is the second most common cancer in men Calgary, AB, Canada; Anatomy, University of Otago , Dunedin, New
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internationally and the fifth leading cause of cancer death. Yet, prostate Zealand; Department of Surgical Oncology, Princess Margaret Cancer
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cancer carries one of the most favorable five-year survival rates of all Centre, Toronto, ON, Canada; Nursing, Dalhousie University , Halifax,
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malignancies. With over 1.1 million men diagnosed annually, focus on NS, Canada; Department of Cellular and Physiological Sciences,
survivorship issues and patient-reported outcomes is becoming increas- University of British Columbia, Vancouver, BC, Canada
S64 CUAJ • June 2020 • Volume 14, Issue 6(Suppl2)