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Unmoderated Posters 2: Uro-Oncology, Pediatrics, Sexual Dysfunction, Transplant
UP-2.6. Table 5. Adverse events (AEs), causality, severity, and type
Number of AEs
Non-serious
Description Notes Mild Moderate Severe Serious Total %
AE “unrelated”
Infection (1) 1
Other - voiding difficulties (2) 1
AE “unrelated” total 1 1 2 8.0%
AE “unlikely related”
Other - progression of myasthenia gravis 1
Other - diarrhea 1
AE “unlikely related” total 1 1 2 8.0%
AE “possibly related”
Infection (3) 1
Bleeding 3
Pain 4
Other - rash 1
AE “possibly related” total 9 9 36.0%
AE “probably related”
Infection (4) 1
Bleeding 4
Pain 6 1
AE “probably related” 11 1 12 48.0%
Totals 22 2 0 1 25 100.0%
(1) Subject had a pre-existing infection from foley catheter use and was excluded by the investigator prior day 0. (2) Subject developed complications of bladder neck erosion from prior
use of artificial sphincter and sling. (3) Subject experienced hematuria, prescribed antibiotic treatment for presumed UTI and was resolved within a week. (4) Subject experienced burning
and was successfully treated with ciprofloxacin, which resolved within a week.
of ≥5.0 cm were included for analysis. Medical records were reviewed from clinical onset to surgical intervention. We sought to investigate
for demographics, including body mass index (BMI), cause of inconti- whether patients from rural regions in Manitoba have worse clinical
nence, history of radiation, Valsalva leak point pressure on urodynamics, outcomes.
degree of leakage preoperatively, at six months and at one year post-AUS
surgery, and AUS revisions to date. Degree of leakage was quantified by
patient-reported number of pads per day. The main study outcome was UP-2.9. Table 1. Baseline characteristics and mortality
the degree of leakage at six months and one year post-AUS implantation. outcomes of rural and urban patients admitted to ICU
Results: A total of 35 patients had a cuff size of ≥5.0 cm. The main reason with Fournier’s gangrene
for incontinence was RP for prostate cancer. Thirty patients had a cuff size
of 5.0 cm and five patients had a cuff size of 5.5 cm. Pre-AUS surgery, Variable Rural Urban p
patients used an average of five pads/day. Pad use was reduced to a mean n=18 (%) n=22 (%)
of 0.9 pads/day at six months and one year after AUS placement, with Age 55.7±13.9 55.9±10.8 0.962
86% reporting 0–1 pads/day usage. There were five revisions performed Sex
to date (one downsizing of cuff, two erosions, one reservoir leak, one
infection). History of radiation, BMI, number of pads preoperatively, and Female 3 (16.7) 3 (13.6)
anticholinergic use postoperatively were not associated with degree of Male 15 (83.3) 19 (86.4) 1.000
leakage one year post-implantation. Colostomy
Conclusions: AUS cuff sizes of ≥5.0 cm does not appear to have a negative
impact on the degree of leakage at six months and one year post-implan- No 15 (83.3) 20 (90.9)
tation. Radiation itself did not have an impact on leakage in these patients. Yes 3 (16.7) 2 (9.1) 0.642
Scrotal debridement
UP-2.9 No 11 (61.1) 17 (77.3)
Location of residence and mortality for patients diagnosed with Yes 7 (38.9) 5 (22.7) 0.267
Fournier’s gangrene
Rachel Wong , Uday Mann , Amanda Eng , Ruben Blachman-Bruan , Charlson score 1.5 (1–3.3) 2 (1.8–6) 0.099
1
2
1
1
Premal Patel 1 LOS 4.7 (2.4–7.1) 4 (1.5–11.5) 0.957
1 Section of Urology, Department of Surgery, University of Manitoba, Mortality
Winnipeg, MB, Canada; Department of Urology, University of Miami
2
Miller School of Medicine, Miami, FL, United States Alive 16 (88.9) 17 (77.3)
Introduction: Fournier’s gangrene (FG) is a multi-bacterial infection Death 2 (11.1) 5 (22.7) 0.427
that leads to necrotizing fasciitis of the perineum and genitalia. Previously Mean ± SD, median (IQR 25–75).
described prognostic factors include patient’s metabolic state and time
CUAJ • June 2020 • Volume 14, Issue 6(Suppl2) S61