Page 5 - CUA 2020_Sexual Dysfunction and Transplant
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Unmoderated Posters 2: Uro-Oncology, Pediatrics, Sexual Dysfunction, Transplant






         UP-2.6. Table 5. Adverse events (AEs), causality, severity, and type
                                                                             Number of AEs
                                                       Non-serious
         Description                           Notes      Mild    Moderate  Severe   Serious   Total      %
         AE “unrelated”
           Infection                            (1)                                     1
           Other - voiding difficulties         (2)        1
         AE “unrelated” total                              1                            1        2       8.0%
         AE “unlikely related”
           Other - progression of myasthenia gravis                  1
           Other - diarrhea                                1
         AE “unlikely related” total                       1         1                           2       8.0%
         AE “possibly related”
           Infection                            (3)        1
           Bleeding                                        3
           Pain                                            4
           Other - rash                                    1
         AE “possibly related” total                       9                                     9      36.0%
         AE “probably related”
           Infection                            (4)        1
           Bleeding                                        4
           Pain                                            6         1
         AE “probably related”                             11        1                          12      48.0%
         Totals                                            22        2         0        1       25      100.0%
         (1) Subject had a pre-existing infection from foley catheter use and was excluded by the investigator prior day 0. (2) Subject developed complications of bladder neck erosion from prior
         use of artificial sphincter and sling. (3) Subject experienced hematuria, prescribed antibiotic treatment for presumed UTI and was resolved within a week. (4) Subject experienced burning
         and was successfully treated with ciprofloxacin, which resolved within a week.
        of ≥5.0 cm were included for analysis. Medical records were reviewed   from clinical onset to surgical intervention. We sought to investigate
        for demographics, including body mass index (BMI), cause of inconti-  whether patients from rural regions in Manitoba have worse clinical
        nence, history of radiation, Valsalva leak point pressure on urodynamics,   outcomes.
        degree of leakage preoperatively, at six months and at one year post-AUS
        surgery, and AUS revisions to date. Degree of leakage was quantified by
        patient-reported number of pads per day. The main study outcome was   UP-2.9. Table 1. Baseline characteristics and mortality
        the degree of leakage at six months and one year post-AUS implantation.  outcomes of rural and urban patients admitted to ICU
        Results: A total of 35 patients had a cuff size of ≥5.0 cm. The main reason   with Fournier’s gangrene
        for incontinence was RP for prostate cancer. Thirty patients had a cuff size
        of 5.0 cm and five patients had a cuff size of 5.5 cm. Pre-AUS surgery,   Variable  Rural  Urban   p
        patients used an average of five pads/day. Pad use was reduced to a mean   n=18 (%)    n=22 (%)
        of 0.9 pads/day at six months and one year after AUS placement, with   Age  55.7±13.9  55.9±10.8  0.962
        86% reporting 0–1 pads/day usage. There were five revisions performed   Sex
        to date (one downsizing of cuff, two erosions, one reservoir leak, one
        infection). History of radiation, BMI, number of pads preoperatively, and   Female  3 (16.7)  3 (13.6)
        anticholinergic use postoperatively were not associated with degree of   Male  15 (83.3)  19 (86.4)  1.000
        leakage one year post-implantation.                   Colostomy
        Conclusions: AUS cuff sizes of ≥5.0 cm does not appear to have a negative
        impact on the degree of leakage at six months and one year post-implan-  No  15 (83.3)  20 (90.9)
        tation. Radiation itself did not have an impact on leakage in these patients.  Yes  3 (16.7)  2 (9.1)  0.642
                                                              Scrotal debridement
        UP-2.9                                                 No                   11 (61.1)  17 (77.3)
        Location of residence and mortality for patients diagnosed with   Yes       7 (38.9)   5 (22.7)  0.267
        Fournier’s gangrene
        Rachel Wong , Uday Mann , Amanda Eng , Ruben Blachman-Bruan ,   Charlson score  1.5 (1–3.3)  2 (1.8–6)  0.099
                  1
                                                         2
                                      1
                            1
        Premal Patel 1                                        LOS                 4.7 (2.4–7.1)  4 (1.5–11.5)  0.957
        1 Section of Urology, Department of Surgery, University of Manitoba,   Mortality
        Winnipeg, MB, Canada;  Department of Urology, University of Miami
                          2
        Miller School of Medicine, Miami, FL, United States    Alive                16 (88.9)  17 (77.3)
        Introduction: Fournier’s gangrene (FG) is a multi-bacterial infection   Death   2 (11.1)  5 (22.7)  0.427
        that leads to necrotizing fasciitis of the perineum and genitalia. Previously   Mean ± SD, median (IQR 25–75).
        described prognostic factors include patient’s metabolic state and time
                                                CUAJ • June 2020 • Volume 14, Issue 6(Suppl2)                S61
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