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CUA GUIDELINE ON ADT: AEs AND MANAGEMENT STRATEGIES 1

QUALITY OF EVIDENCE AND STRENGTH OF RECOMMENDATIONS

• Levels of evidence assigned using criteria from the Oxford

Center for Evidence-based Medicine 2

• Strength of recommendations – subjective consensus

recommendations using best available evidence 2,3

• Strong — supported by high-quality and consistent evidence or

where there is unanimous expert consensus

• Weak — supported by low quality evidence and where there is a

large amount of uncertainty.

• Expert opinion — not supported by explicit evidence but with

sufficient biological plausibility to warrant a recommendation.

1. Kokorovic A, et al. CUAJ 2021 April 21; Epub ahead of print.
2. CEBM, 2018. https://www.cebm.net
2. GRADE Working Group, 2018. http://www.gradeworkinggroup.org