Page 10 - Flipbook
P. 10
DNA repair, PARP inhibition and synthetic lethality
• Loss of DNA repair genes involved in homologous recombination DNA
repair can be an ‘Achilles’ Heel’ for cancer cells
• BRCA2, BRCA1, PALB2, RAD51
ATM is not directly involved in homologous DNA repair but is involved in sensing DNA damage and activating repair