Page 9 - Flipbook

Gemcitabine-Cisplatin (GC) + Drug X not better than GC in

phase 3 trials to date

EORTC 30987 CALGB 90601
GC + Paclitaxel vs GC GC + Bevacizumab vs GC + Placebo

N=506
N=626 1995 2000 205 010
GC + Paclitaxel ORR 55% GC + Bevacizumab did not improve OS or ORR

vs 43% with GC compared to GC + placebo
No significant improvement in OS Median OS ~ 14 months
(15.8 vs 12.7 months)

Bellmunt J et al JCO 2012 Rosenberg J et al. JCO 2021