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Potential Drug–Drug Interactions of AR-targeted

Therapies (cont’d)

Apalutamide Enzalutamide Darolutamide
Drug category Example 1,2
Interactions 3 Interactions 4 Interactions 5

Amlodipine, Nifedipine, Felodipine X X
Calcium channel blockers
Diltiazem, Verapamil X X

Cardiac glycosides Digoxin X X

Hypnotics Alprazolam, Clonazepam, Diazepam X X

Darifenacin, Fesoterodine, Solifenacin,
Overactive Bladder X X
Tolterodine
Pantoprazole, Lansoprazole,
Proton pump inhibitors X X
Omeprazole

Citalopram, Escitalopram X X
Psychiatric medications
Quetiapine, trazodone X X

Rosuvastatin X X *
Statins
Atorvastatin, simvastatin, lovastatin X X

1. FDA. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm;
*If used together, monitor patients more frequently for adverse reactions and consider dose reduction of 2. Lexicomp Online, Pediatric and Neonatal Lexi-Drugs Online, 2020; 3. ERLEADA Product Monograph, 2021;
BCRP substrate drug. 4. XTANDI® Product Monograph, 2021; 5. NUBEQA® (darolutamide) Product Monograph, 2021