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Indirect comparison of gem/cis and gem/carbo in
1 st line metastatic UC (data from KN361)
Median OS for gem/cis or gem/carbo (all chemo) Response rates for carboplatin and cisplatin based
vs gem/carbo therapy
16
60
14
50
Months 10 40
12
%
8
6 30
20
4
2 10
0 0
all chemo (N=352) carbo (N=196) CR PR
cisplatin (n=156) carboplatin (n=196)
Renal impairment and poor performance status were the commonest response for gem/carbo selection (Galsky criteria).
