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The PD-L1 biomarker consists of many different



       biomarkers and should be considered as such.






                                                      Randomized trials testing PD-L1 in UC





                                                           Drug                      setting                  Result



                                                           atezolizumab              Platinum                          -ve
                                                                                     refractory


                                                           atezolizumab              Adjuvant                          -ve



                                                                                      st
                                                           Durvalumab                1 line                            -ve

                                                                                      st
                                                           Pembrolizumab             1 line                            -ve


                                                           nivolumab                 adjuvant                  +ve for ITT and

                                                                                                                  PD-L1+ve

                                                                                      st
                                                           Avelumab                  1 line                    +ve for ITT and
                                                                                     maintenance                  PD-L1+ve
   3   4   5   6   7   8   9   10   11   12   13