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28 CUAJ %u2022 FEBRUARY 2025 %u2022 VOLUME 19, ISSUE 2 Chan et alfour weeks after the initial CO2 laser therapy, the median degree of primary penile curvature had decreased to 35.0%u00b0 (IQR 23.5%u00b0, 57.0%u00b0), representing a mean difference of -4.8%u00b16.2%u00b0 and an overall median reduction in penile curvature of 13.2% (IQR -2.4%, 29.9%), a non-statistically significantly reduction from baseline (p=0.62, z=1.265) (Figure 1); however, at the 52-week time interval after initial CO2 laser therapy, the median degree of penile curvature had decreased to 28.0%u00b0 (IQR 17.50%u00b0, 44.0%u00b0), representing a statistically significant reduction in penile curvature as compared to baseline (p=0.03, z=2.530) (Figure 1). The mean change in penile curvature between baseline and at 52 weeks was -11.6%u00b13.6%u00b0, with an overall median reduction in their penile curvature of 24.3% (IQR 17.0%, 47.5%).International Index of Erectile Function-15 questionnaireThe median overall IIEF-15 scores were not found to be significantly different between baseline (median 59.0, IQR 42.5, 66.5) and at 24-week followup (median 63, IQR 54.5, 67.5, p=0.62, z=1.265) or at week 52 (median 60.0, IQR 53.5, 70.0, p=0.81, z=1.107) (Figure 2a). Similarly, when the IIEF-15 was assessed by its individual domains, patients were not found to have significant changes from baseline as compared to week 24 and one-year followups (Figures 2b%u2013f).Peyronie%u2019s Disease QuestionnaireAlthough a significant difference from baseline (median 26.0, IQR 15.0, 29.5) was not evident for PDQ scores at 24 weeks (median 11.0, IQR 9.0, 22.5, p=0.08, z=2.214), patients did report a significant improvement in their overall PDQ score at the 52-week followup as compared to baseline (median 14.0, IQR 7.0, 22.50, respectively, p=0.03, z=2.530) (Figure 3a). No significant differences existed within PDQ-PD when comparing baseline scores (median 12.0, IQR11.0, 15.0) to followup either at 24 weeks (median 8.0, IQR 11.0, 15.0, p=0.34, z=1.581) or at 52 weeks (median 7.0, IQR 6.0,11.0, p=0.25, z=1.739) (Figure 3b). The PDQ-BD, showed no significant difference from baseline (median 7.0, IQR 4.5, 11.0) to any followup visit (Figure 3c). Patients did not report any significant change in penile pain score. At baseline, patients had a median score of 0.0 (median 7.0, IQR 0.0, 7.0), while at 24 and 52weeks of followup, patients reported a median score of 0.0 (IQR 0.0, 3.5 p>0.99, z=0.9487) and 2.0 (IQR 0.0, 4.0, p>0.99, z=0.4743), respectively (Figure 3d).Figure 1. A comparison of degrees of primarily penile curvature at baseline, 24 weeks, and at 52 weeks following fractional COZ laser therapy. Data is presented as median (interquartile range: Q1, Q3). Medians analyzed using Friedman test. Multiple comparisons performed using Dunn%u2019s multiple comparisons test. *p<0.05. ns: non-significant.0204060Baseline 24 weeks 52 weeksDegrees (%u00ba)Weeksns ns*Figure 2. A comparison of IIEF-15: (a) overall score; (b) erectile function; (c) orgasmic function; (d) sexual desire; (e) intercourse satisfaction; and (f) overall satisfaction domain scores at baseline, 24 weeks, and 52 weeks following fractional CO2 laser therapy. Data is presented as median (interquartile range R: Q1, Q3). Medians analyzed using Friedman test. Multiple comparisons performed using Dunn%u2019s multiple comparisons test. *p<0.05. IIEF: International Index of Erectile Function; ns: non-significant. 0204060800102030400510150510150510150246810Baseline 24 weeks 52 weeksBaseline 24 weeks 52 weeksBaseline 24 weeks 52 weeksBaseline Baseline 24 weeks 52 weeksBaseline 24 weeks 52 weeks24 weeks 52 weeksIIEF Score IIEF Score IIEF Score IIEF Score IIEF Score IIEF Scorensns ns ns nsnsns nsnsnsns nsnsnsns ns nsnsa) b) c)d) e) f)