Page 27 - TSC related Angiomyolipoma - Management Strategies and Case Studies

TSC Affects Multiple Organ Systems 1,2

 Neurologic

• Epilepsy 90%

• Infantile seizures 20-30%
A large
SEGA along

• Brain tumors the midline

- Cortical tubers 90 % of the brain
near the
- SENs 95% foramen of

- SEGAs 6-19% Monro

SEGAs are well circumscribed, slow-

growing, low-grade tumors 3

Can obstruct the CSF circulation,
leading to hydrocephalus

Current intervention options:

• Surgical resection, if feasible
• Shunt implantation

SEGA, subependymal giant-cell astrocytoma; SEN, subependymal nodule

1. Crino. N Engl J Med 2006;355:1345-1356; 2. Leung. J Pediatr Health Care. 2007; 21:108-114; 3. Buccoliero, et al. Neuropathology 2009;29:25-30.