Page 4 - CUA2019 Abstracts - BPH

Poster session 7: bPH, robotics, Infertility, sexual Dysfunction

University, Montréal, QC, Canada; Department of Pediatrics, McGill lesion to the ipsilateral HN (87.2% reduction; 13.8±14.2 mmHg⋅s; p<0.05)
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University, Montréal, QC, Canada; Nutrition Research Division, Health indicating minimal fiber decussation at the aortic plexus.
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Canada, Ottawa, ON, Canada Conclusions: These data suggest that caudal-most LSNs provide the major-
Introduction: Semen quality is a predictor of later pathologies in men, ity of sympathetic innervation to the IUS, and should thus be preferentially
thus it is alarming that sperm counts have declined 60% since 1970. spared in comparison to the IMNs. Future studies seek to verify translat-
A man’s environment can impact the quality of his sperm and reports ability to the clinic.
have shown that the health of his subsequent generations can also be
impaired. Many persistent organic pollutants (POPs) are environmental MP-7.13
endocrine disruptors that could affect men’s fertility. Folic acid (FA) has
been reported to improve sperm production, hence we hypothesized Public interest in men’s health: Analysis of search engine trends
that prenatal exposure to environmentally relevant POPs impair male of common men’s health topics 1
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reproductive health over three generations and FA protects the sperm Max Levitt , Luke Witherspoon , J. Stuart Oake
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from these adverse effects. Division of Urology, University of Ottawa, Ottawa, ON, Canada
Methods: Four treatment groups (n=8) of SD female rats received envi- Introduction: Assessing patient interest in specific healthcare topics or
ronmentally relevant POPs or corn oil before mating and until parturition. finding areas in which patient education is lacking can be challenging.
Diets contained standard (2 mg/kg) or supplemented (6 mg/kg) levels of Internet search engine data may provide an honest and data-rich rep-
FA. F1-F4 generations received standard FA diets without POPs. Fertility resentation of what health topics are currently capturing the interest of
parameters were assessed in F1-F4 males (n=12/group) following mating Canadians. In this study, we used Google Trends data to assess search
with untreated females. Statistical analyses considered main effects and engine patterns of the 10 most common causes of death in men and how
interactions. Significance was p≤0.05. Canadian patients are investigating these topics online.
Results: Prenatal POP exposure decreased sperm viability and motil- Methods: We used Google Trends to assess search data regarding the
ity across three generations. Sperm quality was partly rescued by FA 10 leading causes of death (LCOD) in men according to the CDC in
supplementation in F1-F2, with minimal protection in F3-F4. Fertility 2015, as they were searched between 2014 and 2018 in Canada. Google
was not affected in F1 or F2, but ancestral POPs and/or FA supplementa- Trends is a free online service allowing analysis at a population level of
tion induced poorest pregnancy outcomes of F3 fathers (F4 litters). We all search queries of a term or topic. Interest in a subject is condensed
observed fewer fetuses from POP-exposed lineages, and the combination into a search volume index (SVI). SVI trends can be reported based on
of ancestral POP+FA decreased fertility rate and increased preimplanta- either time or geographic region. SVIs are normalized values with the
tion losses. most popular time or geographic area being given a score of 100, with
Conclusions: Ancestral POP exposure harms male reproductive param- all other variables related to this value.
eters. Although FA supplementation improved many parameters, it only Results: Of the 10 search queries assessed with Google Trends, the top
mitigated several POPs’ effects across four generations. Nonetheless, FA three geographic regions (mean SVI ± standard deviation [SD]) that were
supplementation and male development merit further study, especially searching these topics were Saskatchewan (85.3±10.4), Newfoundland
considering recent reports that, in men, impaired semen quality is an and Labrador (78.9±29.9), and Ontario (75.2±10.8). The most com-
early predictor of disease. monly searched LCOD terms (mean SVI ± SD) of the 10 assessed were
diabetes (80.1±7.5), heart disease (66.2±12.0), and Alzheimer’s disease
(63.7±14.1). Searches about diabetes peaked in December 2015, heart
MP-7.11 disease peaked in February 2018, and Alzheimer’s disease peaked in
Preclinical testing of sympathetic nerve function within the January 2015.
porcine aortic plexus: Implications for retroperitoneal nerve- Conclusions: This study shows some of the first evidence that analysis of
sparing to prevent retrograde ejaculation online activity can reveal real-time interest of the general public regarding
Adam M.R. Groh , Nicholas E. Power , Tyler S. Beveridge 1 men’s health topics. Implications of this work include directing educa-
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1 Department of Anatomy and Cell Biology, University of Western Ontario, tional materials and assistance in policy-making guided by geographical
London, ON, Canada; Department of Surgery, Division of Urology, interest in specific men’s health issues.
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London Health Sciences Centre, London, ON, Canada; Department
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of Oncology, Division of Surgical Oncology, London Health Sciences MP-7.15
Centre, London, ON, Canada
Introduction: Iatrogenic injury to the aortic/superior hypogastric plex- The presence of metabolic syndrome features is not sufficient
uses supplying the internal urethral sphincter (IUS) can cause retrograde to predict the presence of erectile dysfunction or lower urinary
ejaculation, the most prevalent postoperative complication following ret- tract symptoms in men 2 3
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roperitoneal lymph node dissection for testis cancer patients. A prudent Ioana Fugaru , Karim Courtemanche , Peter Chan
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nerve-sparing approach would preserve only the fibers responsible for 2 Faculté de Médecine, Université Laval, Québec City, QC, Canada;
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IUS contraction; however, this is not possible given the specific function Sanford Health Clinics, Clinic, Bismark, ND, United States; Division of
of the constituent nerves remains unknown. Thus, our group endeavoured Urology, McGill University Health Centre, Montréal, QC, Canada
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to investigate the function of two large contributing fibers in bladder neck Introduction: Metabolic syndrome (MS) is a global burden. Erectile dys-
contraction — the intermesenteric nerves (IMNs) and caudal-most lumbar function (ED) is known to share similar features: age, obesity, hyperten-
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splanchnic nerves (LSNs). sion, dyslipidemia, diabetes, and smoking. Among middle-aged and aged
Methods: Using a translational porcine model (n=3; weight=85.6±6.4 men, lower urinary tract symptoms (LUTS) can also cause a significant
kg), we evaluated the relative contributions of the IMNs and LSNs in IUS degree of bother, affecting quality of life. In this Canadian cross-sectional
contraction using a pressure-sensing balloon catheter. Bipolar electro- study, we aim to examine the relationship between MS features and the
stimulation (10 Hz, 3 0mA, 1 ms pulse width, 200 V, 30 s) was applied presence of ED and LUTS.
to the 1) hypogastric nerve (HN); 2) LSN; and 3) IMN in an intact state Methods: Data were collected from 979 consenting adult male vol-
(to determine respective contributions) and following an ipsilateral HN unteers who participated in a free public awareness event in Montréal
lesion (to determine path of innervation). between 2007 and 2013. International Index of Erectile Function (IIEF)-5
Results: The average IUS contraction following LSN stimulation was approx- score, International Prostate Symptom Score (IPSS), Berlin score, body
imately 3.5x greater (157.3±79.7 mmHg⋅s) than the ipsilateral IMN stimula- mass index (BMI), and lipid studies were available for 407 patients. Only
tion (44.0±70.2 mmHg⋅s; p<0.05). Further, LSN stimulation produced an benign prostatic hyperplasia (BPH) treatment-naive patients were consid-
average IUS contraction integral that rivaled the response generated by ered in this study (n=389). One point was given each of the following:
ipsilateral HN stimulation (82.1% of total; 193.4±107.9 mmHg⋅s; p>0.05). BMI ≥30, diabetes type II, total cholesterol level ≥6.2 mmol/L, high-
Lastly, the response from the LSN was significantly reduced following a density lipoprotein (HDL) level <1.03 mmol/L, and Berlin high-risk group.
CUAJ • June 2019 • Volume 13, Issue 6(Suppl5) S133