Page 2 - CUA2019 Abstracts - Oncology-Kidney

Poster session 9: Kidney, Penis, and testis Cancer

Reference of Abdominal Imaging, Joint Department of Medical Imaging, University
1. Christodoulidou M, Sahdev V, Houssein S, et al. Epidemiology Health Network, University of Toronto, Toronto, ON, Canada
of penile cancer. Curr Probl Cancer 2015;39:126-36. https://doi. Introduction: Resection of residual masses (>1 cm) after chemotherapy
org/10.1016/j.currproblcancer.2015.03.010 is recommended in patients with testicular non-seminomatous germ cell
tumour (NSGCT). Traditionally, resections in the abdomen and chest are
MP-9.5 performed as separate surgical procedures. The aim of this study was to com-
pare a simultaneous vs. sequential approach to residual mass resections.
Oncological outcomes of patients with sporadic, non-metastatic Methods: A retrospective review was performed of all patients who under-
renal cell carcinoma with renal vein or inferior vena cava went both retroperitoneal and thoracic resection of post-chemotherapy
tumour thrombus residual masses at the Princess Margaret Cancer Centre between 2002
Benjamin Shiff , Rodney H. Breau , Alan I. So , Frédéric Pouliot , Anil and 2018. Patients were divided into two groups: group 1 – simultane-
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Kapoor , Jun Kawakami , Jean-Baptiste Lattouf , Ricardo A. Rendon , ous (combined retroperitoneal and thoracic resections at the same sit-
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Simon Tanguay , Ranjeeta Mallick , Rahul Bansal 1 ting) and group 2 – sequential (retroperitoneal and thoracic resections
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1 Urology, University of Manitoba, Winnipeg, MB, Canada; Urology, at separate dates).
University of Ottawa, Ottawa, ON, Canada; Urologic Sciences, University Results: During the study period, 35 simultaneous and 17 sequential
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of British Columbia, Vancouver, BC, Canada; Urology, Université Laval, resections were performed. The mean age of the patient at surgery was
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Québec City, QC, Canada; Department of Surgery, McMaster University, 28 years (range 16–61). The mean followup from final surgery was
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Hamilton, ON, Canada; Urology, University of Calgary, Calgary, AB, 48.3 months (range 1–239). Histology revealed teratoma in 38 (73.1%)
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Canada; Surgery, Université de Montréal, Montréal, QC, Canada; patients, necrosis in eight (15.4%), and viable tumour in six (11.5%).
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8 Urology, Dalhousie University, Halifax, NS, Canada; Urology, McGill Discordant pathology findings between thoracic and abdominal resec-
University, Montréal, QC, Canada; Ottawa Hospital Research Institute, tions were noted in 16 (30.8%) patients. There was no difference in overall
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Ottawa, ON, Canada mean length of operating time (minutes) between the two groups (635 vs.
Introduction: Tumour extension into the venous circulation is a well- 405+218; p=0.77). There was no difference in overall blood loss (ml)
described feature of renal cell carcinoma (RCC), and aggressive surgical between the two groups (1904 vs. 2258+301; p=0.39). There was no
management has been shown to provide cure in a substantial propor- difference in overall mean length of stay (days) between the two groups
tion of patients. However, the factors that contribute to variability in (14.8 vs. 9.5+8.2; p=0.72). Patients who underwent sequential surgeries
outcomes are poorly understood. This study was conducted to examine had a longer time from consent to completion of surgery (8.4 months vs.
factors associated with survival in patients who had undergone surgery 2.1 months; p=0.0001). Overall, there was a recurrence rate of 30.8%
for non-metastatic RCC with venous tumour thrombus. (n=16). Two patients have died of testicular cancer.
Methods: The Canadian Kidney Cancer information system (CKCis) data- Conclusions: Simultaneous resection of retroperitoneal and thoracic post-
base was used to identify a historical cohort of patients who under- chemotherapy metastases is a feasible and safe approach. It does entail
went radical nephrectomy and renal vein or inferior vena cava (IVC) multidisciplinary co-operation and a longer primary procedure.
tumour thrombectomy for non-metastatic pathological T3 RCC from
2011–2018. Association of level of tumour thrombus was examined
with recurrence-free survival (RFS) and overall survival (OS). Univariate MP-9.7
and multivariate analyses were performed. Determining generalizability of the Canadian Kidney Cancer
Results: Of the 165 patients identified from the database who satisfied the information system (CKCis) to the entire Canadian kidney cancer
study criteria, 100, 37, and 28 patients had level 0–1, 2, and 3–-4 throm- population
bus, respectively. Mean age was 65 (standard deviation [SD] 10.9) years. Camilla Tajzler , Anil Kapoor , Ranjeeta Mallick , Beau Ahrens, Luke T.
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Fuhrman tumour grade 4 was associated with poor RFS on univariate Lavallée , Rodney H. Breau , Naveen Basappa , Simon Tanguay , Daniel
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analysis (hazard ratio [HR] 0.47; 95% confidence interval [CI] 0.24–0.94; Heng , Frédéric Pouliot , Darrel E. Drachenberg , Georg Bjarnason ,
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p=0.032), although this association only trended towards significance Denis Soulieres , Nicholas E. Power , Patrick Richard , Christian
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on multivariate analysis when adjusted for tumour size, margin status, Kollmannsberger , Antonio Finelli , Lori A. Wood 14
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and level of tumour thrombus (HR 0.51; 95% CI 0.24–1.09; p=0.081). 1 Division of Urology, McMaster Institute of Urology, Hamilton, ON,
Thrombus level did not impact the RFS or OS. Predicted five-year survival Canada; Division of Urology, University of Ottawa, Ottawa, ON,
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rates were 63.7%, 68.3%, and 60.8% for tumour thrombus level 0–1, Canada; Department of Oncology, University of Alberta, Edmonton, AB,
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2, and 3–4, respectively, with no significant difference between them Canada; Division of Urology, McGill University, Montréal, QC, Canada;
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(log-rank test p-value=0.25). 5 Department of Oncology, University of Alberta, Calgary, AB, Canada;
Conclusions: According to our data, level of venous tumour thrombus is 6 Division of Urology, Université Laval, Québec City, QC, Canada; Division
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not associated with survival metrics in patients undergoing surgery for of Urology, University of Manitoba, Winnipeg, MB, Canada; Department
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non-metastatic RCC with renal vein or IVC thrombus. Tumour grade may of Oncology, University of Toronto, Toronto, ON, Canada; Department
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be associated with RFS in these patients. of Medicine, Université de Montréal Hospital Centre, Montréal, QC,
Canada; Division of Urology, Western University, London, ON, Canada;
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MP-9.6 11 Division of Urology, Université Sherbrooke, Sherbrooke, QC, Canada;
Department of Oncology, The University of British Columbia, Vancouver,
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Simultaneous vs. sequential retroperitoneal and thoracic BC, Canada; Division of Urology, University of Toronto, Toronto, ON,
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resection of post-chemotherapy residual masses in patients with Canada; Department of Medicine, Dalhouse University, Halifax, NS,
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metastatic non-seminomatous germ cell tumours of the testis Canada
Ishan Aditya , Gregory Nason , Laura Donahoe , Marc De Perrot , Canadian Kidney Cancer information system (CKCis)
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Michael A. Jewett , Philippe Bedard , Aaron R. Hansen , Peter Chung , Introduction: The Canadian Kidney Cancer information system (CKCis)
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Padraig Warde , Lynn Anson-Cartwright , Joan Sweet , Martin O’Malley , has prospectively collected data on patients with renal cell carcinoma
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Robert Hamilton 1 (RCC) since January 1, 2011 from 14 academic centres in six provinces.
1 Division of Urology, Department of Surgery, Princess Margaret Cancer CKCis data have been used by Canadian researchers for several research
Centre, Toronto, ON, Canada; Division of Thoracic Surgery, Toronto General initiatives. The goal of this study was to determine if the CKCis cohort
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Hospital, University of Toronto, Toronto, ON, Canada; Division of Medical appears generalizable to the entire Canadian RCC population, specifically
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Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, regarding demographic and geographic distributions.
Canada; Division of Radiation Oncology, Princess Margaret Cancer Centre, Methods: The CKCis cohort was analyzed up to December 31, 2017.
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Toronto, ON, Canada; Division of Pathology and Lab Medicine, University Baseline demographics were examined. Geographic info was analyzed,
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Health Network, University of Toronto, Toronto, ON, Canada; Division including province and rural vs. urban residence via postal code info (sec-
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CUAJ • June 2019 • Volume 13, Issue 6(Suppl5) S141