Page 20 - CUA 2020_Onco_Bladder

Moderated Posters 3: Uro-Oncology

MP-3.14 interquartile range [IQR] 25). Mean followup was 19.6 years. There were
Long-term testis cancer survivors in Canada: Mortality risks in numerous demographic differences between exposed and unexposed
a large, population-based cohort individuals (Table 1). Majority of individuals with TC had seminoma his-
1
1
1
2
Roderick Clark , Arnon Lavi , Tina Luu Ly , Shiva M. Nair , Khalil Hetou , tology (n=1170, 74.1%). Individuals with non-seminoma TC were more
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Michael Haan , Nicholas E. Power 1 likely to die of cardiovascular disease (Table 2) during the study period
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1 Division of Urology, Department of Surgery, Schulich School of Medicine (HR 4.46; 95% confidence interval [CI] 2.10–9.43; p<0.01), while indi-
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and Dentistry, Western University, London, ON, Canada; Department of viduals with seminoma were not (HR 2.34; 95% CI 0.98–5.49; p=0.054).
Sociology, Western University, London, ON, Canada Risk of death from non-TC cancer was increased for both seminoma (HR
Introduction: Introduction of cisplatin chemotherapy revolutionized treat- 7.38; 95% CI 4.53–12.06; p<0.01) and non-seminoma (HR 7.03; 95% CI
ment of testis cancer (TC). Cohorts received these revolutionary treat- 4.58–10.78; p<0.01). Multivariate analysis controlling for demographic
1,2
ments are now reaching middle and later stages of their lives. Early and parameters confirmed these findings (Table 3).
long-term sequelae of these treatments have been defined, but very long- Conclusions: TC survivorship is associated with increased risk of death
3-5
term (>10-year) mortality risks are still a topic of debate. Our objective was from other malignancies. Non-seminoma survivorship is associated with
to compare cause of death for TC patients to those without TC in Canada. an increased risk of death from cardiovascular disease.
Methods: We conducted a population-level, retrospective cohort study References
using the Canadian Census Health and Environment Cohort (CanCHEC). 1. Hanna N, Einhorn LH. Testicular cancer: A reflection on 50 years of
Exposed individuals were those diagnosed with TC from 1969–2010. Main discovery. J Clin Oncol 2014;32:3085-92. https://doi.org/10.1200/
outcome was cause of death between 1991 and 2010. Exposed individu- JCO.2014.56.0896
als were matched with unexposed individuals (not diagnosed with TC by 2. Verdecchia A, Francisci S, Brenner H, et al. Recent cancer sur-
2
1991). Demographic characteristics were compared using χ /t-tests. Cox vival in Europe: A 2000–02 period analysis of EUROCARE-4 data.
proportion hazards models were generated. Forward selection hazard Lancet Oncol 2007;8:784-96. https://doi.org/10.1016/S1470-
ratios (HR) explored interaction between covariates and main effect. 2045(07)70246-2
Results: We identified 2 678 410 individuals (1950 exposed and 2 676
460 unexposed) meeting our inclusion criteria (median age: 44 years,
MP-3.14. Table 1. Demographic baseline characteristics
Cohort Testis cancer Non-testis cancer p
(n=2 678 410) (n=1950) (n=2 676 460)
Age (median years, IQR) 44 (25) 36 (15) 44 (25) <0.0001
Male sex 1 302 245 (48.6%) 1950 (100%) 1 300 295 (48.6%) <0.0001
Marital status (count) <0.0001
Single 459 845 (17.2%) 535 (27.4%) 459 310 (17.2%)
Married 1 734 475 (64.7%) 1220 (62.3%) 1 733 250 (64.7%)
Divorced 281 520 (10.5%) 175 (9%) 281 340 (10.5%)
Widow 202 570 (7.6%) 15 (0.7%) 202 555 (7.6%)
Education <0.0001
No high school 996 010 (37.2%) 525 (26.7%) 995 485 (37.2%)
High school 949 325 (35.4%) 790 (40.4%) 948 540 (35.4%)
Post-secondary, non-university 390 775 (14.6%) 280 (14.4%) 390 495 (14.6%)
University 342 295 (12.8%) 360 (18.5%) 341 940 (12.8%)
Region <0.0001
Ontario 992 385 (37%) 785 (40.3%) 991 600 (37%)
Quebec 691 295 (25.8%) 310 (15.9%) 690 985 (25.8%)
West Coast (BC) 331 350 (12.4%) 265 (13.6%) 331 085 (12.4%)
Prairies (Man, Sas, Alb) 435 475 (16.3%) 410 (21%) 435 065 (16.3%)
Atlantic Canada (NB, NFLD, PEI, NS) 221 005 (8.3%) 170 (8.7%) 220 835 (8.3%)
Territories (NWT, Yuk) 6905 (0.2%) 10 (0.5%) 6895 (0.2%)
Urbanicity 0.1939
Rural 604 805 (22.6%) 445 (22.8%) 604 360 (22.6%)
Small urban (<30 000) 359 660 (13.4%) 255 (13.1%) 359 405 (13.4%)
Urban (30 000-99 999) 244 220 (9.1%) 190 (9.7%) 244 025 (9.1%)
Urban (100 000-499 999) 284 025 (10.6%) 235 (12.1%) 283 795 (10.6%)
Urban (500 000+) 1 185 700 (44.3%) 825 (42.3%) 1 184 875 (44.3%)
Immigration status <0.0001
Canadian-born 2 088 360 (78%) 1,665 (85.4%) 2 086 695 (78%)
Immigrant 590 050 (22%) 285 (14.6%) 589 765 (22%)

CUAJ • June 2020 • Volume 14, Issue 6(Suppl2) S95