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Current Treatment Algorithm

















                                                                              Avelumab*                                  Enfortumab

                                                       SD/PR/CR
                 Platinum-Based                                                                                             Vedotin*

                  Chemotherapy
                                                                                                                                                                        Taxane
                       4-6 cycles                           PD



                                                                           Pembrolizumab
                                                                                                                         Erdafitinib**
                                                                           OR Erdafitinib**










              Platinum-ineligible → BSC







                 • *Currently available by special access program

                 • **For patients with known FGFR mutations/fusions, limited testing availability
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