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ADT and metabolic/cardiovascular events
▪ Association between ADT and diabetes, coronary heart disease, myocardial infarction, sudden death, and stroke in a observational
study of 37443 men from 01/2001 to 12/2005, including 39% treated with ADT.
2
Adjusted hazard ratio 1.5 No ADT
GnRHa
1
Orchiectomy
0.5 MAB
Antiandrogens
0
Diabetes CHD Myocardial Infarction Cardiac death
CHD: coronary heart disease, ADT: androgen deprivation therapy.
Keating N et al. J Natl Cancer Inst 2010;102: 39 – 46
