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NOTICE OF POTENTIAL DRUG-DRUG INTERACTIONS
Darolutamide
Drug effects Drug effects Darolutamide effects Darolutamide effects
Avoid combination: Monitor/Modify: Monitor/Modify: Avoid combination:
Rosuvastatin 4 Clozapine 1 Clarithromycin 1 Carbamazepine 1
Nimodipine 1 Itraconazole 1,4 Phenytoin 1
Ketoconazole 1
Enzalutamide
Drug effects Drug effects Enzalutamide effects Enzalutamide effects
Avoid combination: Monitor/Modify Monitor/Modify Avoid combination:
Atorvastatin 5 Alfuzosin 1 cont.: Gemfibrozil 5
Bisoprolol 5 Alprazolam 1 Oxcarbazepine 1
Carbamazepine a,1,5 Amiodarone 1 Oxycodone 1 Monitor/Modify:
Lefiunomide
1
Clarithromycin b,1,5 Amlodipine 1 Perampanel 1
Clonazepam 5 Apixaban 1 Prednisone 1
Clopidogrel 5 Aripiprazole 1 Quetiapine 1
Dabigatran 5 Brexpiprazole 1 Repaglinide 1
Diazepam 5 Chlordiazepoxide 1 Risperidone 1
Digoxin 5 Citalopram 1 Rivaroxaban 1
Diltiazem 5 Clozapine 1 Saxagliptin 1
Doxycycline 5 Codeine 1 Sertraline 1
Dronedarone 1 Cyclosporine 1 Sildenafil 1
Felodipine 5 Darifenacin 1 Silodosin 1
Fentanyl 1,5 Dexamethasone 1 Solifenacin 1
Haloperidol 5 Diclofenac 1 Tadalafil 1
Itraconazole 1 Doxazosin 1 Tamsulosin 1
Lurasidone 1 Erythromycin 1 Trazodone 1
Nifedipine 1,5 Escitalopram 1 Triazolam 1
Nimodipine 1 Ethosuximide 1 Voriconazole 1
Omeprazole 5 Fesoterodine Zolpidem 1
1
Phenobarbital 5 Flurazepam 1 Zopiclone 1
Phenytoin 1,5 Fluvastatin 1
Primidone 5 Gliclazide 1
Propranolol 5 Glimepiride 1
Simvastatin 5 Glyburide 1
Ticagrelor 1 Ketoconazole 1
Tramadol 5 Lansoprazole 1
Valproic acid 5 Linagliptin 1
Verapamil 5 Losartan 1
Vorapaxar 1 Lovastatin 1
Warfarin 5 Methadone 1
a. Enzalutamide may decrease carbamazepine concentration. Carbamazepine may decrease enzalutamide concentration.
b. Enzalutamide may increase serum concentrations of clarithromycin active metabolite(s) and decrease clarithromycin concentration. Clarithromycin may increase enzalutamide concentration.
Recommended actions/actions taken regarding the drug interaction(s), other drug interactions Practitioner Name
not listed, or additional notes:
Disclaimer: The drug-drug interaction tables presented in this resource include a selection of medications commonly encountered in patients undergoing treatment for prostate cancer and are not
comprehensive in nature. This resource is intended only to supplement the knowledge of healthcare professionals regarding drug therapy.
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References: [1] UpToDate, Inc. Lexicomp Drug Interactions. Available at: www.uptodate.com. Accessed Sep. 2020. [2] ZYTIGA Product Monograph. Nov.13, 2020.
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[3] ERLEADA Product Monograph. Nov.13, 2020. [4] NUBEQA Product Monograph. Feb.19, 2020. [5] XTANDI Product Monograph. Jun.1, 2020.
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Canadian Urological Association
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This resource has been made possible through funding from Bayer Inc. in the form of an educational grant.
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© Copyright 2020, The Canadian Urological Association January 2021