Page 155 - PRESENTATION

HORRAD: ADT + Concurrent Radiation Therapy (RT)

During the Advanced Prostate Cancer Consensus Conference 2017, 69% of

panelists suggested that RT local treatment should be regarded as the appropriate

treatment for patients with newly diagnosed oligometastatic prostate cancer.

• Objective: Determine if OS is

prolonged by adding local treatment 100 ADT
ADT + radiation therapy

of the primary prostatic tumour with Log rank p=0.02

EBRT to ADT 80 Median time to PSA progression:

RT group 15 mo (95% CI: 11.8-18.2)

60 vs 12 mo (95% CI: 10.6-13.4)
• Results: This RCT comparing ADT to PSA progression (%)

ADT + EBRT to the prostate in 40

patients with primary bone mPCa:
20

• Did not show a significant difference in

OS 0

• But did show a prolonged time to PSA 0 24 48 72

progression Time from randomisation (mo)

ADT 214 56 14 5

ADT + radiation 210 72 32 13
therapy

156 Boeve LM et al. Eur Urol 2019; 75:410-418