Page 54 - PRESENTATION
P. 54

PSA Doubling Time












                      • Progression of CRPC to                                                                                       Patients with shorter PSADT are at greater



                            bone metastases is                                                                                                     risk for bone metastasis or death



                            common




                                                                                                                                            3.0
                      • Median survival for men                                                                                             2.8


                            with CRPC metastatic to                                                                                         2.6



                            bone is ~ 1.5 to 2 years                                                                                        2.4






                      • Important to identify who                                                                       Increasing Risk  Relative Risk for Bone  Metastasis or Death  2.2



                            is at greater risk for bone                                                                                     2.0



                            metastases                                                                                                      1.8

                                                                                                                                            1.6



                                                                                                                                            1.4


                                                                                                                                            1.2

                                                                                                                                                   20          18          16           14          12          10            8           6           4           2            0


                                                                                                                                                                                              PSADT (months)



                                                                                                                                                                                            Shorter PSADT







        55     Smith MR et al. J Clin Oncol 2013; 31:3800-3806
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