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Potential Drug–Drug Interactions of AR-targeted

Therapies (cont’d)

Apalutamide Enzalutamide Darolutamide
Drug category Example 1,2
Interactions 3 Interactions 4 Interactions 5

Amlodipine, Nifedipine, Felodipine ✓ ✓
Calcium channel blockers
Diltiazem, Verapamil ✓ ✓

Cardiac glycosides Digoxin ✓

Hypnotics Alprazolam, Clonazepam, Diazepam ✓ ✓

Darifenacin, Fesoterodine, Solifenacin,
Overactive Bladder ✓ ✓
Tolterodine
Pantoprazole, Lansoprazole,
Proton pump inhibitors ✓ ✓
Omeprazole

Citalopram, Escitalopram ✓ ✓
Psychiatric medications
Quetiapine, trazodone ✓ ✓

Rosuvastatin ✓ ✓ *
Statins
Atorvastatin, simvastatin, lovastatin ✓ ✓

1. FDA. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm;
*If used together, monitor patients more frequently for adverse reactions and consider dose reduction of 2. Lexicomp Online, Pediatric and Neonatal Lexi-Drugs Online, 2020; 3. ERLEADA Product Monograph, 2019; 4. XTANDI® Product
BCRP substrate drug. Monograph, 2019; 5. NUBEQA® (darolutamide) Product Monograph, 2020