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Implementing NAC
• Cisplatin-based combination chemotherapy
• MVAC (Methotrexate, Vinblastine, Adriamycin, Cisplatin):
4 cycles x 4 weeks
• Gemcitabine/Cisplatin: 4 cycles x 3 weeks
• ddMVAC (dose dense MVAC): 4 cycles x 2 weeks
DO NOT USE CARBOPLATIN FOR
NEOADJUVANT PLATINUM-BASED CHEMOTHERAPY
• Endorsed by CUA, EAU, AUA and GUMOC
Chang et al, AUA Guidelines 2017
Kulkarni et al, CUAJ 2019
Jiang et al, Bladder Cancer 2020
Witjes et al, EAU Guideines 2018
