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Case Introduction





                                                                                                           Patient history (2016):


                                                                                                           • 59-year-old presents with weight loss (3-month
                                                                                                               duration)

                                                                                                                      • PSA 26 ng/mL

                                                                                                                      • Biopsy shows Gleason 8 (4 + 4)

                                                                                                                      • CT/BS negative


                                                                                                           • Received RT to the primary, PSA was then
                                                                                                               undetectable


                                                                                                           • Now, 66 years old, returns with rising PSA and back
                                                                                                               pain


                                                                                                                      • PSA 22 ng/mL
                                                                                                                      • CT/BS reveals three spinal lesions, no

                                                                                                                          lymphadenopathy, no visceral metastases



                                                                                                                        How would you stratify this patient?

                                                                                                                      What treatments would you consider?





                                                                                                                       PSA, prostate-specific antigen; CT, computed tomography; BS, bone scan; RT, radiotherapy
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