Page 7 - Presentation

Prostate-specific membrane antigen (PSMA)

• Type II integral membrane protein

• Expressed on the surface of prostate epithelial cells

• Glutamate carboxypeptidase

• Undergoes endocytosis

• Limited expression in non-prostate tissues such as

salivary glands, duodenum

• PSMA is upregulated in most prostate tumors

• > 85% of prostate cancer cells are PSMA-positive

• Increased expression correlated with:

• Increasing grade and metastases

• Post-treatment with ADT

• Disease progression and the transition to mCRPC

• Poor prognosis