Page 5 - mCSPC EN Booklet-Feb 2021 Web
P. 5
Table of Contents
Introduction 5
Managing Metastatic Castration-Naïve and
Castration-Sensitive Prostate Cancer (mCNPC
mCSPC) 7
Course of Disease 7
Definitions and Terminology 8
Newly Diagnosed mCSPC Management Algorithm 9
Androgen-Deprivation Therapy 10
Staging Newly Diagnosed Prostate Cancer 11
Assessment of Prognosis 12
Multidisciplinary Consultation 13
Treatment of Newly Diagnosed mCSPC 14
Applying Guidance to Index Patients 18
Imaging During mCSPC Treatment 22
Sequencing Considerations 22
Key Trials in mCNPC and mCSPC 23
Clinical Trials 23
ARCHES 24
CHAARTED 25
ENZAMET 26
GETUG-AFU 15 27
HORRAD 28
LATITUDE 29
STAMPEDE 30
TITAN 33
Drug Profiles 35
Baseline Assessment 35
Prostate Cancer Therapies 36
Abiraterone acetate + prednisone 36
Apalutamide 38
Enzalutamide 40
Docetaxel 42
Bone-targeted Agents 44
Alendronate 44
Denosumab 46
Zoledronic acid 48
Continued on next page
Practical Approaches to Managing mCNPC and mCSPC 3
