Page 64 - mCSPC EN Booklet-Feb 2021 Web

Resources

ECOG Performance Status

Grade ECOG Performance Status

0 Fully active, able to carry on all pre-disease performance without restriction
Restricted in physically strenuous activity but ambulatory and able to carry out
1 work of a light or sedentary nature, eg, light housework, office work

Ambulatory and capable of all selfcare but unable to carry out any work activities;
2
up and about more than 50% of waking hours
Capable of only limited selfcare; confined to bed or chair more than 50% of
3 waking hours

4 Completely disabled; cannot carry on any selfcare; totally confined to bed or chair
5 Dead
Oken M, et al. Am J Clin Oncol. 1982. https://ecog-acrin.org/resources/ecog-performance-status

Classifying Burden of Disease and Risk in
mCNPC/mCSPC

Trial Classification Based on Burden of Disease/Risk
CHAARTED High-volume defined as ≥1 criteria: Low-volume defined as no high-volume
• Visceral metastases criteria (all other mCNPC/mCSPC)
• ≥4 bone lesions with ≥1 beyond
the vertebral bodies and pelvis
LATITUDE High-risk defined as ≥2 criteria: Low-risk (LATITUDE) defined as
• Visceral metastases <2 high-risk criteria:
• ≥3 bone lesions • Visceral metastases
• Gleason score ≥8 • ≥3 bone lesions
• Gleason score ≥8

FRAX Fracture Risk Assessment Tool
®
Online tool to calculate the ten-year probability of fracture with BMD.

FRAX ®
Osteoporosis Canada: https://osteoporosis.ca/health-care-professionals/tools/frax/
University of Sheffield: https://www.sheffield.ac.uk/FRAX/tool.aspx?country=19

Practical Approaches to Managing mCNPC and mCSPC 57