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CHAARTED: Docetaxel in High vs Low Volume HSPC

OS – High Volume OS – Low Volume

1.0 HR, 0.63 1.0 HR, 1.04

(95% CI, 0.50–0.79) (95% CI, 0.70–1.55)
p <0.0001 p = 0.86
0.8 (median OS 51.2 mo) 0.8 (median OS 63.5 mo)
ADT + doce
ADT + doce
Proportion alive 0.6 ADT alone Proportion alive 0.6 (median OS NR)
ADT alone

0.4
0.4

0.2 (median OS 34.4 mo) 0.2
ADT + doce ADT + doce
ADT alone ADT alone
0.0 0.0

12 24 36 48 60 72 84 96 108 12 24 36 48 60 72 84 96 108

No. at risk OS months OS months

ADT + doce 263 239 202 151 91 41 16 5 2 0 134 127 112 94 64 26 12 2 0 0
ADT alone 250 215 156 104 59 19 9 1 0 0 143 137 122 94 67 26 12 1 0 0

16.8 months 0 months

Kyriakopoulos CE, et al. J Clin Oncol 2018;36:1080-1087.