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Progression free and overall survival for chemotherapy
and atezolizumab in advanced UC.
Arm A Arm C Arm A Arm C
Atezo + plt/gem Placebo + plt/gem Atezo + plt/gem Placebo + plt/gem
(n = 451) (n = 400) (n = 451) (n = 400)
PFS events, n (%) 334 (74) 326 (82) OS events , n (%) 235 (52) 228 (57)
a
Stratified HR 0.82 (0.70, 0.96) Stratified HR (95% 0.83 (0.69, 1.00)
(95% CI) P = 0.007 (one-sided) CI) P = 0.027 (one-sided) b
Not statistically significant
due to one sides
and alpha spend 0.024
