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U.S. PLCO (Prostate, Lung, Colorectal, and Ovarian)



                Cancer Screening Trial







                       • 76,685 men aged 55-74 years


                       • annual screening for 6 years or “usual care”



                       • median f/u of 13 years by 2009


                       • The cumulative incidence rate for PCa was slightly higher in the


                          screened group with no difference in PCa mortality






                       • More men in the control arm had PSAs



                       • Younger men benefited from PSA screening
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