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Dekalo & Welk




        Table 1. Pre- and post-TURP PVRs and Qmax
                            Preoperative                Postoperative followup at 4–8 weeks Final postoperative followup
                                                                                     (median 3.5 years)
                            Qmax (mL/sec) PVR (mL)      Qmax (mL/sec)  PVR (mL)      Qmax (mL/sec) PVR (mL)
        All men (n=14)       8 (IQR 6–13)  820 (IQR 691–985)  17 (IQR 7–18)*  143 (IQR 60–430)*  14 (IQR 6–17)*  337 (IQR 5–550)*
        Men with UDS confirmed  8.5 (IQR 6–17)  849 (IQR 600–990)  17 (IQR 10–17)*  333 (IQR 40–430)*  15 (IQR 6–16)*  300 (IQR 25–760)*
        BOO (n=5)
        *p<0.01 compared to preoperative value. BOO: bladder outlet obstruction; IQR: interquartile range; PVR: postvoid residual; Qmax: maximal flow rate; TURP: transurethral resection of the
        prostate; UDS: urodynamic study.
       toperative Clavien-Dindo complications ≥3, median weight of   PVRs, but we believe our data will help the urologist in
       prostate tissue removed was 8.3 g (IQR 6.2–11), and duration   decision-making and patient counselling when encountering
       of postoperative catheterization was <5 days for all men.At   this clinical scenario.
       the first postoperative followup (4–8 weeks after surgery), the   Our study limitations include the small sample size, which
       PVR was significantly lower and the Qmax was significantly   limited our ability to further analyze subgroups. Our inclu-
       higher (Table 1). Patients had a median postoperative followup   sion criteria mean that these results are not generalizable
       period of 3.5 years (IQR 2–7) and at the patient’s final follo-  to all men with a large PVR. Finally, there is no comparison
       wup, the PVR continued to be significantly lower compared   group, and it is possible that with conservative management,
       to the preoperative measurement (Table 1); only one man   these men would not have developed any further urinary
       had a PVR higher than his preoperative value (by 30 mL).   dysfunction over time.
       Similar improvements were seen in the men with confirmed
       BOO on UDS (Table 1). No one needed to use catheters   Conclusions
       throughout the followup period and there were no bladder
       neck contractures or evidence of upper tract deterioration or   In our small cohort of selected men with elevated PVRs and
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       obstructive uropathy.                                 mild or no LUTS, TURP improved PVRs and Qmax pos---
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                                                             toperatively, and this improvement was maintained during
       Discussion                                            a median followup of over three years.
       This small pilot study demonstrates that men with mild urin-  Competing interests: The authors do not report any competing personal or financial interests
       ary symptoms and elevated PVRs experienced numerical   related to this work.
       improvement in their PVRs and Qmax after TURP, and this
       benefit appears to be sustained over a median of three years.
       This study supports the concept that first, TURP is safe in   This paper has been peer-reviewed.
       these patients; and second, that it may prevent deterioration
       in bladder function in the future. It is important to note that
       this was a carefully selected group of men who participated   References
       in shared decision-making and were motivated to try and
       avoid catheter use in the future.                      1.  Stoffel JT, Peterson AC, Sandhu JS, et al. AUA white paper on nonneurogenic chronic urinary retention:
         The natural history of chronic urinary retention is not   Consensus definition, treatment algorithm, and outcome endpoints. J Urol 2017;198:153-60.https://
                                                                doi.org/10.1016/j.juro.2017.01.075
       well-understood. Several studies suggest that men with   2.  Stoffel JT. Non-neurogenic chronic urinary retention: What are we treating? Curr Urol Rep 2017;18:74.
       high PVRs and “high-pressure” chronic urinary retention   https://doi.org/10.1007/s11934-017-0719-2
       (characterized by hydronephrosis) or severe LUTS may be   3.  Dellimore KH, Helyer AR, Franklin SE. A scoping review of important urinary catheter induced complications.
       more likely to benefit from a TURP.  Authors have argued   J Mater Sci Mater Med 2013;24:1825-35. https://doi.org/10.1007/s10856-013-4953-y
                                      8,9
       that conservative management of large PVRs is appropriate;   4.  Cornu JN, Ahyai S, Bachmann A, et al. A systematic review and meta-analysis of functional outcomes
       however, almost a quarter of men progress and need inter-  and complications following transurethral procedures for lower urinary tract symptoms resulting from
                                                                benign prostatic obstruction: An update. Eur Urol 2015;67:1066-96. https://doi.org/10.1016/j.
              10
       vention.  It is unclear what proportion of men with benign   eururo.2014.06.017
       prostatic hyperplasia (BPH) go on to develop an acontractile   5.  Abello A, DeWolf WC, Das AK. Expectant long-term followup of patients with chronic urinary retention.
       detrusor muscle and require clean intermittent catheteriza-  Neurourol Urodyn 2019;38:305-9. https://doi.org/10.1002/nau.23853
       tion (CIC), and if the natural history of their bladder dysfunc-  6.  Lerner LB, McVary KT, Barry MJ, et al. Management of lower urinary tract symptoms attributed to benign
       tion could have been altered with earlier intervention. If   prostatic hyperplasia: AUA guideline part I-Initial workup and medical management. J Urol 2021;206:806-
                                                                17. https://doi.org/10.1097/JU.0000000000002183
       we accept PVR as a surrogate marker of detrusor function,   7.  Nitti VW. Pressure flow urodynamic studies: The gold standard for diagnosing bladder outlet obstruction.
       which may end in an acontractile bladder, then our results   Rev Urol 2005;7:S14-21.
       would suggest that TURP may reduce this risk. Our cohort of   8.  Negro CLA, Muir GH. Chronic urinary retention in men: How we define it and how does it affect treat-
       patients represents only a small subset of men with elevated   ment outcome. BJU Int 2012;110:1590-4. https://doi.org/10.1111/j.1464-410X.2012.11101.x
       318                                       CUAJ • October 2022 • Volume 16, Issue 10
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