Page 2 - Kidney Cancer Research Network of Canada (KCRNC) consensus statement on the role of cytoreductive nephrectomy for patients with metastatic renal cell carcinoma

CUAJ – Consensus Statement Mason et al
KCRNC consensus: Cytoreductive nephrectomy for mRCC

several important questions remain surrounding the appropriate application of CN,
particularly with regards to optimal patient selection and the timing of surgery.
Herein, the Kidney Cancer Research Network of Canada (KCRNC) provides
consensus recommendations on the role of CN in patients with mRCC in order to guide
clinicians who manage patients with advanced RCC.

Methods

Evidence acquisition
A comprehensive search was conducted to identify studies relevant to the development of
this consensus statement. Databases searched included MEDLINE, EMBASE, Cochrane
Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and
SCOPUS. The search strategy was designed and conducted by an experienced librarian
with input from the consensus statement authors. The full search strategy can be found in
the appendix.

Consensus statement development
This consensus document was developed to address six questions related to CN that were
judged to be the most relevant to patient care:
1) Should patients with mRCC be offered CN and what is the optimal patient
selection and timing?
2) Is there a role for CN in patients with non-clear cell mRCC?
3) Is there a role for biopsy prior to CN?
4) Is there a role for concomitant regional lymph node dissection during CN?
5) Is there a preferred surgical approach for CN?
The statements contained herein were developed by consensus of the authors of
this document, which include stakeholders across multiple specialties.