Page 10 - Presentation

VARIOUS DEFINITIONS OF BCR AFTER RP USED IN CLINICAL

PRACTICE AND TRIALS

Based on rising PSA Based on successive
Based on single PSA (1 value followed by rises in PSA Based on consecutive
st
values: any higher value) (not nec. consecutive) rises in PSA

• ≥ 0.2 ng/mL • ≥ 0.1 ng/mL and • 2 successive rises, • 3 consecutive rises of

• ≥ 0.4 ng/mL rising final ≥ 0.2 ng/mL any incremental
amount

• ≥ 0.6 ng/mL • ≥ 0.2 ng/mL and • 3 successive rises of • 3 consecutive rises
rising any amount
with failure date
• ≥ 0.4 ng/mL and • 3 successive rises back-dated to

rising ≥ 0.1 midpoint between the
date of the last

nonmeasurable PSA
value and date of the
first of the 3 PSA rises

Stephenson AJ, et al. J Clin Oncol 2006;24:3973-8; Han M, et al. Urol Clin North Am 2001;28:555-65; Roehl KA, et al. J Urol 2004;172:910-4;
Amling CL, et al. J Urol 2001;165:1146-51; Kupelian PA, et al. J Clin Oncol 2002;20:3376-85; Stamey TA, et al. JAMA 1999;281:1395-1400; Freedland SJ, et al.
Urology 2003;61:365-9; Hull GW, et al. J Urol 2002;167:528-34; ASTRO Consensus Panel. Int J Radiat Oncol Biol Phys 1997;37:1035-41