Page 13 - Monitoring Prostate Cancer to Guide Treatment Decision-Making

NCCN Recommendations for Clinical Assessment and

Staging Work-up: Patients with Metastatic Disease

INITIAL PROSTATE CANCER WORK-UP
DIAGNOSIS

• DRE Imaging
• PSA • Bone imaging (if equivocal results on initial bone
• Prostate biopsy scan, consider plain films, CT, MRI, or
• Life expectancy estimation F-18 NaF PET/CT)
• Family history*
• Pelvic ± abdominal imaging

Molecular Testing
• Consider tumour testing for homologous

recombination gene mutations and for
microsatellite instability (MSI) or mismatch repair
deficiency (dMMR)

• Consider germline genetic testing

*With consideration of cancers related to DNA repair gene abnormalities (eg, BRCA1/2, Lynch syndrome)
Adapted from NCCN Guidelines Version 4. 2018. Prostate Cancer.
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