Page 5 - Practical Approaches to Managing Castration-Resistant Prostate Cancer (CRPC)

Table of contents

Introduction 5

Managing Non-Metastatic Castration-Resistant
Prostate Cancer (nmCRPC) 7
Definition: Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC) 7
nmCRPC Patient Identification and Categorization of Disease Risk 7
nmCRPC Management Algorithm 8
Management of Patients with nmCRPC 9
nmCRPC Patient Assessment 9
Management Principles in Patients with Low-Risk (Non-High-Risk)
or High-Risk Disease 9
Patients with High-Risk nmCRPC (PSADT ≤10 months) 10
Patients with Low-Risk (Non-High-Risk) nmCRPC (PSADT >10 months) 10
Bone Health in nmCRPC 11

Managing Metastatic Castration-Resistant
Prostate Cancer (mCRPC) 13
Definition: Metastatic Castration-Resistant Prostate Cancer (mCRPC) 13
mCRPC Patient Identification and Management Considerations 13
mCRPC Management Algorithm 14
Management of Patients with mCRPC 15
mCRPC Patient Assessment 15
Treatment Options: mCRPC 15
Imaging During mCRPC Therapy 17
Bone Health in nmCRPC 18
Bone-Targeted Therapy in Patients with CRPC and Bone Metastases 18
Supportive Care Therapies 18
Oncologic Emergency 18

Treatment Sequencing 19
Considerations for Treatment Selection 19
Sequencing Analyses: Limited Evidence 19

Drug Therapy 21
Baseline Assessment Prior to Initiating Drug Therapy 21
Androgen-Deprivation Therapy (ADT) 22
Androgen Receptor-Axis Targeted (ARAT) Agents 22
Abiraterone 22
Apalutamide 25
Enzalutamide 28

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Practical Approaches to Managing CRPC 3