Page 17 - New Treatment Options for Adults and Children with Overactive Bladder

Antimuscarinic Mode of Action

• All antimuscarinics

1. The efferent connection of the pelvic nerve is

inhibited due to anticholinergic action resulting in
relaxation of bladder smooth muscle.
Propiverine and Oxybutynin

2. In addition, propiverine and oxybutynin inhibit the

calcium influx and modulates the intracellular
calcium in urinary bladder smooth muscle cells

causing musculotropic spasmolysis

Non-specific anti-muscarinic

Propiverine product monograph