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RWE Analysis of PSMA-PET in a SPARTAN-like Population


                Negative by Conventional Imaging: N = 200






                                                                                                      Category Based on                                               All Patients
                                                                                                      miTNM Stage, n (%)                                                N = 200

                                                                                                      M0                                                                 91(46)
                                                                                                      T0N0M0 (no prostate cancer lesion)                                  4 (2)
                                                                                                      TrN0M0                                                             48 (24)
                                                                                                      T0N1M0                                                             13 (7)
                                                                                                      TrN1M0                                                             26 (13)
                                                                                                      Any M1                                                            109 (55)
                                                                                                      T0N0M1                                                             31 (16)
                                                                                                      T0N1M1                                                             42 (21)
                                                                                                      TrN0M1                                                              9 (5)
                                                                                                      TrN1M1                                                             27 (14)

                                                                                                      N/M disease extent
                                                                                                      Unifocal (1 lesion)                                                29 (15)
                                                                                                      Oligometastatic (2–3 lesions)                                      28 (14)
                                                                                                      Multiple/disseminated (≥4 lesions)                                 91 (46)

                                                                                                         PSMA-PET was positive in 196 of 200 (98%) study patients
                                                                                                                                          overall


                                                                                                       75% of patients had metastatic (55% distant, 20% regional)
                                                                                                               disease despite negative conventional imaging

  Slide provided by Dr. Saad.
  PSMA-PET, prostate specific membrane antigen positron emission tomography; RWE, real-word evidence
  Hadaschik B, et al. Oral presentation at EAU; Mar 15-19, 2019; Barcelona, Spain. [Abstract 523]
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