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ENZAMET Overall Survival: Enzalutamide Significantly



                Reduced the Risk of Death by 33%





                                                                                                                                     Enzalutamide
                                                  1.00                                                                               NSAA




                                              Proportion Alive  0.75  0.72 (0.68 to 0.76)             0.80 (0.75 to 0.83)
                                                                      Proportion Alive at 36 months (95% CI)


                                                                                                         Enzalutamide
                                                   0.50
                                                                             NSAA



                                                  0.25
                                                                    Hazard ratio = 0.67 (95% CI: 0.52 to 0.86)
                                                                    Log-rank p=0.002

                                                   0.00

                                                              0           6          12         18         24         30         36         42         48


                                                                                                     Months
                                   Number at risk

                                                 NSAA 562        551        531        501        452        311        174         86          32
                                    Enzalutamide 563        558        541        527        480                         340          174       106         45
   48   49   50   51   52   53   54   55   56   57   58