Page 8 - SLIDES

VESPER SUMMARY and SECONDARY OUTCOMES

• Primary outcome: 3 year PFS

• ddMVAC vs GC

• 3 yr PFS 64% vs 56%, HR=0.77 (95% CI, 0.57-1.02), p=0.066)

• pCR 42% vs 36%, p=0.2

• OS pending 5 yr follow up

• Secondary outcome:

• Organ-confined response (< ypT3N0): dd-MVAC arm favoured

(77% vs 63%, p=0.001)