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Recommended Dose Modifications for Adverse Events
Olaparib (tablets) 1 Rucaparib 2 Niraparib 3 Talazoparib 4
Starting dose 300 mg twice daily 600 mg twice daily 300 mg once daily 1 mg once daily
First dose reduction 250 mg twice daily 500 mg twice daily 200 mg once daily 0.75 mg once daily
100 mg once daily
400 mg twice daily 0.5 mg once daily
Further reductions 200 mg twice daily Then If reduction to <100 mg Then
300 mg twice daily daily is needed, 0.25 mg once daily
discontinue drug
1. Olaparib (Lynparza) Product monograph; 2. Rucaparib (Rubraca) US prescribing information; 3. Niraparib (Zejula) Product monograph; 4. Talazoparib (Talzenna) Product monograph
