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AVAILABLE HORMONAL THERAPIES FOR PC TREATMENT
• Surgical castration
• Medical castration
• Gonadal androgen ablation
• LHRH agonists: leuprolide, goserelin, and triptorelin
• LHRH antagonists: degarelix, relugolix
• Androgen receptor antagonists (AA)
• First generation: bicalutamide
• Second generation: enzalutamide, apalutamide and darolutamide
• Androgen synthesis inhibitors (CYP17 adrenal inhibitors):
abiraterone acetate, ketoconazole
LHRH Luteinizing hormone-releasing hormone Kokorovic A, et al. CUAJ 2021 April 21; Epub ahead of print.