Page 24 - CUA Presentation
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Importance of BOTH Germline and Somatic Testing





                                      Germline HRRm Testing Only Will Miss Patients with Somatic Mutations




           • Whole-blood testing identifies germline but not somatic mutations

           • 50% or more of the BRCA HRR gene alterations present in mCRPC may be somatic in origin


           • Testing for germline mutations only would miss a large proportion of patients with a mutation, who could benefit
               from PARP inhibitor treatment


           • ctDNA and tumour testing capture patients with both germline and somatic mutations
                  •   ctDNA analysis provides both somatic and germline data because the germline is used as a reference. If likely germline alterations are detected,

                      patients may be reflex germline tested










                   Whole-blood testing will                                                                                              ctDNA and tumour testing

                    not identify all patients                                                                                           gives the opportunity for all

                     with an HRR mutation                                                                                             patients with an HRR mutation
                                                                                                                                                 to be identified










                                                       ctDNA, circulating tumour DNA; mCRPC, metastatic castration-resistant prostate cancer; HRRm, homologous recombination repair mutation
                                                                                      Abida W et al. JCO Precis Oncol. 2017;1:1-16.
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