Page 24 - CUA Presentation
P. 24
Importance of BOTH Germline and Somatic Testing
Germline HRRm Testing Only Will Miss Patients with Somatic Mutations
• Whole-blood testing identifies germline but not somatic mutations
• 50% or more of the BRCA HRR gene alterations present in mCRPC may be somatic in origin
• Testing for germline mutations only would miss a large proportion of patients with a mutation, who could benefit
from PARP inhibitor treatment
• ctDNA and tumour testing capture patients with both germline and somatic mutations
• ctDNA analysis provides both somatic and germline data because the germline is used as a reference. If likely germline alterations are detected,
patients may be reflex germline tested
Whole-blood testing will ctDNA and tumour testing
not identify all patients gives the opportunity for all
with an HRR mutation patients with an HRR mutation
to be identified
ctDNA, circulating tumour DNA; mCRPC, metastatic castration-resistant prostate cancer; HRRm, homologous recombination repair mutation
Abida W et al. JCO Precis Oncol. 2017;1:1-16.