Page 8 - CUA Presentation

Implications for Carriers of BRCA1/2 Mutation: Prognosis and Familial Risk

• Increased relative • Increased risk for • Increased

risk for prostate other cancers at a familial risk for
cancer by age 65 younger age: cancer(s)

• Breast, pancreatic,
➢ 2.5-8.6 fold

vs noncarriers 1-3 melanoma

Risk for more aggressive disease 4,5

• Higher Gleason score

• More nodal involvement and distant metastases at diagnosis

• Higher likelihood of developing metastatic disease at 5 years
• Higher risk of prostate cancer-specific mortality

1. Breast Cancer Linkage Consortium J Nat Cancer Inst 1999;91:1310-6. 2. Kote-Jarai Z et al. Br J Cancer 2011;105:1230-4.
3. van Asperen CJ et al. J Med Genet 2005;42:711-9. 4. Castro E et al. Eur Urol 2015;68:186-93. 5. Castro E et al. J Clin Oncol 2013;31:1748-57.