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Stage- wise Drug and Therapy Development in Prostate Cancer
                                  Agents moved upfront- fine tuning
                                  Clarity on sequencing
                                  Targeted Therapy







                                                                                     Newly diagnosed

                                                                                          mHSPC



                                                                                             Primary
                                                Unmet Needs                                progressive
                                                                                             mHSPC
                                         Localised or locally      Biochemical                                                               Terminal
                                         advanced prostate                                                          mCRPC                     disease
                                              cancer                recurrence                                                                (death)


                                                                                          nmCRPC












                                                                                                                          Hong JH, Kim IY. Korean J Urol. 2014;55:153-60.
                          mCRPC, metastatic castration-resistant prostate cancer;               Mottet N, et al. EAU/ESTRO/ESUR/SIOG Guidelines on Prostate Cancer 2017.
                          mHSPC, metastatic hormone-sensitive prostate cancer;             Available from: http://uroweb.org/guideline/prostate-cancer. Accessed February 2018.
                          nmCRPC, non-metastatic castration-resistant prostate cancer.
                                                                                                                Adapted from: Scher HI, et al. J Clin Oncol. 2016;34:1402-18.
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