Page 12 - Flipbook

1- Understanding the biology was key

E2
CUL2
Rbx1 VHL complex
disrupted
Elongin B Elongin C

VHL protein β-domain Mutant α-domain

HIFα
accumulation

Activation of hypoxia-inducible genes

VEGF Glut1 PDGF

Autocrine Growth
Angiogenesis Glucose Transport Stimulation