Page 13 - Flipbook

1-Understanding the biology was key

Naive Activated Exhausted Reinvigorated
T Cell T Cell T Cell T Cell

Negative Positive • T-cell clonal expansion
Positive Signal Signal • Cytokine secretion
Signal • Effector functions
• Tumour-directed migration

PD-1 PD-1
Signal TCR CD28 Signal BMS-936558
AG
1 MHC B7 2 PD-L1
PD-L1

• T-cell clonal expansion
• Cytokine secretion
• Effector functions
• Tumour-directed migration

APC or APC or APC or
Tumour cell Tumour cell Tumour cell

AG, antigen; APC, antigen presenting cell; MHC, major histocompatibility complex; Adapted from Brahmer JR et al. J Clin Oncol. 2010;28:3167-3175 and
PD-1, programmed death-1; TCR, T-cell receptor.
Keir ME et al. Annu Rev Immunol. 2008;26:677-704.