Page 12 - FLIPBOOK

Study limitations

• This is a retrospective analysis of a purchased database containing real-world data from

clinical practice between January 2007 to June 2016. The data are not randomized or

controlled.

• Data are from multiple institutions, therefore standardizing instrumentation and T assay

methodology was not feasible, but the size of large data set should have reduced any

impact on conclusions.

• There may be analytical issues associated with pooling data from an

extended duration.

• As T was monitored infrequently, it is possible that patients who were not responding well

from a clinical or PSA biomarker standpoint were more likely

to undergo T measurement, potentially resulting in bias.

SOURCE: Crawford E.D. et al.,The Journal of Urology. Vol. 203, 743-750, April 2020.