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PSA Case 2: 65 year old man
Radiotherapy to prostate, We have

Diagnosed with pelvic nodes, and large left iliac bone met reported on
metastatic CRPC FH identified: cross-sensitivity/
Multiple bone mets cross-resistance
BRCA2 germline mt of PARPi with

Goserelin and bicalutamide Identified: Olaparib carboplatin (Fong

et al, JCO 2010)

----31 months----

CRPC after 1 year
Multiple bone mets New met in left iliac bone,
‘Go home to die’ enlarged retroperitoneal nodes

Abiraterone
Docetaxel and
figitumumab

Radium 223

Good response to
Eribulin
Abiraterone (36m)

Time ➔