Page 8 - Presentation

Deficiencies in DNA damage repair can contribute to carcinogenesis

Ionizing Replication
UV light Carcinogens
radiation errors

DNA damage

DNA Damage Response (DDR) leads to DNA repair

Perfect repair Failed repair Imperfect repair

Reduced efficacy of DDR
Cell death Mutation
promotes carcinogenesis

Panneerselvam J et al. DCLK1 and DNA damage response. 2020; p.3.