Page 9 - Presentation

Gene alterations in certain DNA damage repair pathways affect selection of optimal

therapy and/or familial cancer risk in patients with prostate cancer

Several DNA damage repair pathways exist

1.Repair of single-stranded breaks occurs via: 2.Repair of double-stranded breaks occurs via:

• Mismatch repair (MMR) • Homologous recombination repair (HRR)

• Nucleotide excision repair (NER) • Nonhomologous end joining (NHEJ)

• Base excision repair (BER)

O’Connor MJ. Mol Cell 2015;60:547–60.