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Management of Side Effects of AR-Targeted


                Therapies – Hypothyroidism (Apalutamide)










                                                                • Common symptoms:


                                                                       • Fatigue/sluggishness, cold intolerance,


                                                                          constipation, hair loss, weight gain

                                                                • Monitor TSH at baseline and as clinically


                                                                   indicated.


                                                                       • If abnormal:

                                                                              • Test for total T3, free T4, total T4


                                                                              • Refer to PCP for thyroid hormone

                                                                                 supplementation













                   PCP = Primary care physician
                   TSH = Thyroid-stimulating hormone                                                                                               ERLEADA Product Monograph]  2021
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