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•Co-primary Endpoint: OS With Durvalumab vs
Platinum based chemotherapy vs durvalumab in front line UC
Chemotherapy in the PD-L1 High Population
1.0
Durvalumab (n=209) Chemotherapy (n=207)
0.8 Median OS, months (95% CI) 14.4 (10.4–17.3) 12.1 (10.4–15.0)
HR (95% CI) 0.89 (0.71–1.11)
Probability of OS 0.6 51% 36%
55%
0.3039
Log-rank P value*
0.4
29%
0.2
Durvalumab
Chemotherapy
0.0
0 3 6 9 12 15 18 21 24 27 30 33 36 39 42 45 48 51
Time from randomisation (months)
Number at risk
Durvalumab 209 176 143 123 112 97 87 81 74 68 66 63 61 39 19 6 1 0
Chemotherapy 207 186 161 126 101 86 74 66 57 51 48 44 42 27 16 8 2 0
14
*Considered statistically significant if p < 0.0301.